effects of high and low doses of folic acid on the soluble receptor activator of nuclear factor-kappa b ligand/osteoprotegerin ratio during pregnancy

نویسندگان

nazila fathi maroufi

amir ghorbanihaghjo

manizheh sayyah melli

maryam vaezi

چکیده

background: pregnancy associated osteoporosis (pao) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. soluble receptor activator of nuclear factor-kappa b ligand (srankl) to osteoprotegerin (opg) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporosis and would be modified with folic acid supplementation. this study was done to compare the effects of high dose (5mg/day) and low dose (0.5 mg/day) folic acid in the rankl/opg ratio and tumor necrosis factorα (tnfα) concentration during pregnancy. methods: forty-five pregnant women who visited the al-zahra hospital, tabriz iran, from september 2013 to november 2014 were assigned into two groups in this randomized, double-blind, clinical trial, included women who took 5 mg/day (group1) and who took 0.5 mg/day (group 2) folic acid supplementation before pregnancy until 36 th pregnancy. the biochemical variables in serum of pregnant women were measured before and at the end of the study. the study was registered in the iranian registry of clinical trials (irct) as id, irct2013122315903n1. results: opg levels were significantly higher compared with the baseline value ( p =0.008), although srankl ( p <0.001), tnfα ( p =0.005) and srankl/opg ratio ( p <0.001) reduced significantly with high dose of folic acid supplementation. a significant positive correlation was observed between the decreased rankl and tnfα levels (r=0.451, p =0.031) at the end of study in high dose group. conclusion: high dose of folic acid supplementation could decrease bone resorptive biomarkers and may prevent pao in pregnant women by increasing opg and decreasing srankl and tnfα.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy

BACKGROUND Pregnancy Associated Osteoporosis (PAO) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. Soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) to Osteoprotegerin (OPG) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporo...

متن کامل

Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Levels in Peri-Implant Crevicular Fluid

Background: Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases. Objective: To determine the presence of RANKL in peri-implant crevicular fluid samples of implants with peri-implan...

متن کامل

the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance

this study compared the different effects of form-focused guided planning vs. meaning-focused guided planning on iranian pre-intermediate students’ task performance. the study lasted for three weeks and concentrated on eight english structures. forty five pre-intermediate iranian students were randomly assigned to three groups of guided planning focus-on-form group (gpfg), guided planning focus...

15 صفحه اول

study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats

nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...

15 صفحه اول

the effects of time planning and task complexity on accuracy of narrative task performance

هدف اصلی این تحقیق بررسی تاثیر برنامه ریزی زمانی، هم چنین افزایش میزان پیچیدگی تکالیف در نظر گرفته شده بصورت همزمان، بر دقت و صحت و پیچیدگی عملکرد نوشتاری زبان آموزان می باشد. بدین منظور، 50 نفر از دانش آموزان دختر در رده ی سنی 16 الی 18 سال به عنوان شرکت کنندگان در این زمینه ی تحقیق در نظر گرفته شدند و به دو گروه آزمایشی و کنترل بصورت اتفاقی تقسیم شدند. اعضای گروه آزمایشی هر دو تکلیف ساده و پی...

the effects of keyword and context methods on pronunciation and receptive/ productive vocabulary of low-intermediate iranian efl learners: short-term and long-term memory in focus

از گذشته تا کنون، تحقیقات بسیاری صورت گرفته است که همگی به گونه ای بر مثمر ثمر بودن استفاده از استراتژی های یادگیری لغت در یک زبان بیگانه اذعان داشته اند. این تحقیق به بررسی تاثیر دو روش مختلف آموزش واژگان انگلیسی (کلیدی و بافتی) بر تلفظ و دانش لغوی فراگیران ایرانی زیر متوسط زبان انگلیسی و بر ماندگاری آن در حافظه می پردازد. به این منظور، تعداد شصت نفر از زبان آموزان ایرانی هشت تا چهارده ساله با...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of public health

جلد ۴۶، شماره ۴، صفحات ۵۱۷-۵۲۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023